The research work of Dr Ghosh is centered around on cells-nanoparticles interaction, based on Reverse Charge Parity Counterions (RCPC) model as previously proposed in the case of proteins-nanoparticles interaction.

Dr Ghosh and co-workers based on their work using lymphoblastoid Raji cell line and counterions-conjugated charged iron oxide nanoparticles (IONPs), have reported that among differently coated charged nanoparticles, only positively charged nanoparticles with chloride counterions caused sever toxicity to cancer cell lines, which fortunately, did not show toxicity to peripheral blood cells (PBMC). This was attributed to a plaussibility that the cancer cell membranes over-express negative charge, which is usually not true for normal cell membranes.

To explore chloride counterions-conjugated cationic nanoparticles as a tool for cancer therapy, Dr Ghosh and co-workers we wanted to add more functionalities on nano surfaces such as protection against the protein corona formation in the physiological environment, fluorescence tagging to name a few, They first PEGylated the nanoparticles and then grafted with counterions-conjugated ionic molecules. These surface modified nanoparticles were used for the interaction with zwitterionic DPPC multi-layer vesicles (mimicked the cell membrane),and to study the effects on their temperature dependent Lbeta-to-Lalpha phase transition using DSC technique. The DSC results clearly revealed that interaction with CPC/PEG-coated nanoparticles had caused shifting of the transition temperature to a higher value, which again validated the RCPC model.

Dr Ghosh and his collaborators at the Kolkata Centre designed experiments with counterions-conjugated ionic nanoparticles to overcome Radiation Induced Bystander Effects(RIBEs), in which NPs stands for the chloride counterions-conjugated cationic nanoparticles.